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KMID : 0358419720150020003
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Korean Journal of Obstetrics and Gynecology
1972 Volume.15 No. 2 p.3 ~ p.9
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Comparison of the Pregnancy Rates Following Diethylstilbestrol, Sexovid and Clomid Treatments in the Anovulatory Patients
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Abstract
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Two hundred. eighty five anovulatory patients were treated with 3 methods (continuous administration.of the small amount of estrogen and thyroid hormone, sexovid and clomid therapy). The patients were divided into three groups: (1) those with oligomenorrhea; (2) those with anovulatory cycle; and (3) those with first degree of amenorrhea.
The results of the treatment in pregnancy rates were as follows: 1) Combined therapy with diethylstilbestrol and thyroid hormone
a) Total pregnancy rate was 23.9% 39 cases became pregnant in 163.
b) Pregnancy rates in the three groups.
In those with oligomenorrhea, anovulatory cycle and first degree of amenorrhea, pregnancies occurred in 28.8%, 27.3/06 and 8.6% respectively. c) Ovulations occurred in about 43%.
2) Sexovid therapy
a) Total pregnancy rate was 27.6% : 16 cases conceived in 58.
b) In those with oligomenorrhea, anovulatory cycle and first degree of amenorrhea, the pregnancy rates were 37.5%, 35.3% and 16.0% respectively. c) Inauction rate of ovulation was about 63%.
3) Clomid therapy.
a) Total pregnancy rate was 32.8%(21 cases in 64).
b) In those with oligomenorrhea anovulatory cycle and first degree of amenorrhea, the pregnancy rates were 36.8%, 39.3% and 17.6% respectively. c) Ovulations occurred in about 80%. Especially in the three groups, the results of the treatment with sexovid and clomid in the pregnancy rates were similarity effective as a whole.
Although the inducing rates of ovulation are most prominent in the treatment with clomid or sexovid among the three methods, the pregnancy rates were not parallel to them.In the pregnancy rates, there were no statistic significant differences between three methods of the treatment or three groups of anovulation type, probably suggesting the reason of antiestrogenic effect of sexovid or clomid.
Even in the continuous combined therapy with diethylstilbestrol and thyroid hormone, if used reasonably according to indications under exact diagnosis, the pregnancy rate may be similarily effective like sexovid or clomid therapy. It may be reasonable to initiate sex-steroid therapy followed by sexovid or clomidd therapy in the anovulatory patients.
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